Macon sits at the crossroads of two of Missouri's four-lane roads of the future, Highway 63 and Highway 36(the Chicago/Kansas City Expressway). Highway 63 is an important north-south artery linking southeast and northeast Missouri. Highway 36 is an east-west connection from Chicago to Kansas City, just recently transitioning from two to four-lane.  On August 2, 2005, the four lane from Macon to Hannibal was approved by majority vote, to be completed Fall of 2010.  A bypass reflects Macon's progressive attitude and enables both commercial and tourist traffic to move quickly and safely through the area. Macon is an hour's drive from Interstate 70 and is easily accessible to most major markets throughout the United States.

To illustrate the accessibility Macon offers to northern Missouri, many government agencies, both state and federal, have regional offices here. Additionally, Gully Trucklines serves the Midwest from its terminal in Macon.

Macon's airport is functional and efficient with a 3,500 foot, lighted runway, with plans to expand to 4,200 feet in the future.

Local manufactures utilize the airport to transport company executives. In addition, St. Louis' Lambert Field and Kansas City International airport are both international airports, just minutes away by air and within 2.5 hours by road.

To transport heavy goods, the Burlington-Northern and Santa Fe Railroads maintain service to Macon.  Macon is within 60 miles of a duty-free terminal at the Missouri River for transporting by barge.

But access is more than physical. Macon was the first city in the State of Missouri to have total fibre optics to every home and every business furnished by Chariton Valley Telecom.  Chariton Valley has expanded its services to now include Chariton Valley Television (CVTV) which provides local information, coverage and special features to cable customers.